WAY 316606

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM[1].

Product Specifications

CAS Number

[915759-45-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SFRP-1; Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WAY-316606.html

Purity

99.24

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CC(S(=O)(C2=CC=CC=C2)=O)=CC=C1C(F)(F)F)(NC3CCNCC3)=O

Molecular Formula

C18H19F3N2O4S2

Molecular Weight

448.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52 (1), 105-116.|[2]Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44 (6) :1063-8.