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Anti-Histone H3.3 Antibody FL650 Conjugate

Our Anti-Histone H3.3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N158/28. It detects human, mouse, and rat Histone H3.3, and is purified by Protein A chromatography. It is great for use in IHC.

Product Specifications

Background

H3 Histone Family Member 3B is encoded by the gene H3.3B. H3.3B is a member of the histone H3 family. H3.3B contains introns and its mRNA is polyadenylated. H3.3B is a variant histone H3, and is a replication-independent histone. H3.3B is deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. H3.3B is expressed in 9 organs with the highest expression in the spleen. Diseases associated with H3.3B include Chondroblastoma, Clear Cell Chondrosarcoma, Bone Giant Cell Sarcoma, Malignant Giant Cell Tumor, and brain stem cancer.

Short Description

Our Anti-Histone H3.3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N158/28. It detects human, mouse, and rat Histone H3.3, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Histone H3.3

Gene Name

H3f3b H3.3b

UniProt

P84245

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 83-93 (LRFQSAAIGAL) of rat Histone H3.3 (accession number P84245)

Target

Histone H3.3

Clonality

Monoclonal

Isotype

IgG1

Clone

N158/28

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Epigenetics

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

15 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Histone H3.1

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

IHC Quality Control

1

RRID

AB_2939835

Frequently Asked Questions

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