Anti-Gs Protein, Alpha Subunit Antibody FL490 Conjugate

Guanine nucleotide-binding protein G (s) subunit alpha isoforms short or Gs protein α subunit is encoded by the gene GNAS. Gsα is one of three subunits that make up a guanine nucleotide binding protein (Gprotein) . The other proteins are a beta and a gamma subunit. G proteins are further divided into families depending on the type of α subunit included, G (S) alpha, G (Q) alpha, G (I) alpha, and G (12) alpha. Gsα functions as a transducer of numerous signaling pathways that are controlled by g protein coupled receptors (GPCRs) by coupling receptors to adenylyl cyclase and results in increased levels of the signaling molecule cAMP. Diseases associated with GNAS include Mccune-Albright Syndrome and Progressive Osseous Heteroplasia.

Our Anti-Gs protein, alpha subunit mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N192/12. It detects mouse and rat Gs protein, alpha subunit, and is purified by protein a chromatography. It is great for use in ICC.

Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit (accession number P04896-2) produced recombinantly in E. Coli

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.