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Anti-Kir2.2 K+ Channel Antibody

Our Anti-Kir2.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N124B/38. It detects rat Kir2.2 K+ channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Product Specifications

Background

ATP-sensitive inward rectifier potassium channel 12or Kir2.2 is encoded by the gene KCNJ12. Kir2.2 is a member of the inward rectifier potassium ion channel family and plays a role controlling the resting membrane potential in muscle cells and neurons. Kir2.2 is an integral membrane protein that is expressed in heart, brain and in aortic endothelial cells. In brain, Kir2.2 is expressed throughout the forebrain and cerebellum. Diseases associated with KCNJ12 include Smith-Magenis Syndrome and Leber Congenital Amaurosis 16.

Short Description

Our Anti-Kir2.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N124B/38. It detects rat Kir2.2 K+ channel, and is purified by protein a chromatography. It is great for use in WB, ICC, ELISA.

Synonyms

ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K (+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12)

Gene Name

Kcnj12 Irk2

UniProt

P52188

Host

Mouse

Reactivity

Rat

Immunogen

Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (accession number P52188)

Target

Kir2.2 K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

N124B/38

Type

Primary Antibody

Applications

WB, ICC, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

48 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity against Kir2.1 or Kir2.3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_2130486

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