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Anti-Dicer Antibody FL650 Conjugate

Our Anti-Dicer mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N167/7. It is KO validated, detects human, mouse, and rat Dicer, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Endoribonuclease Dicer or Dicer 1, Ribonuclease III is encoded by the gene DICER1. DICER1 acts as a double stranded (ds) ribonuclease and plays a role in short post transcriptional gene silencing. DICER1 cleaves full length dsRNA and miRNA into smaller moleclues 21-23 nucleotides in length, called siRNAs and microRNAs. Dicer1 is expressed in a variety of tissues, including brain. Diseases associated with this gene include Pleuropulmonary Blastoma, Glow Syndrome and Wilms Tumor.

Short Description

Our Anti-Dicer mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N167/7. It is KO validated, detects human, mouse, and rat Dicer, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Endoribonuclease Dicer (EC 3.1.26.3) (Double-strand-specific ribonuclease mDCR-1)

Gene Name

Dicer1 Dicer Mdcr

UniProt

Q8R418

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer (accession number Q8R418) produced recombinantly in E. Coli

Target

Dicer

Clonality

Monoclonal

Isotype

IgG1

Clone

N167/7

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Epigenetics

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

215 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939727

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