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Anti-GABA-B-R1 Antibody

Our Anti-GABA (B) R1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N93A/49. It is KO validated, detects human and mouse GABA (B) R1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Gamma-aminobutyric acid type B receptor subunit 1 or GABA BR1 is encoded by the gene GABBR1. GABA BR1 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid) . It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR1 is highly expressed in many tissues including eye, atrium, ventricle, lung and colon. In brain, wide expression is seen with high levels in the cerebral cortical layers and hippocampus. Cellularly, it is found at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABBR1 include Temporal Lobe Epilepsy and Persistent Vegetative State.

Short Description

Our Anti-GABA (B) R1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N93A/49. It is KO validated, detects chicken, human, mouse, rabbit, and rat GABA (B) R1, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)

Gene Name

Gabbr1

UniProt

Q9Z0U4

Host

Mouse

Reactivity

Chicken, Human, Mouse, Rabbit, and Rat

Immunogen

Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (accession number Q9Z0U4) produced recombinantly in E. Coli

Target

GABA (B) R1

Clonality

Monoclonal

Isotype

IgG1

Clone

N93A/49

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Neurotransmitter Receptors

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.111

Molecular Weight

115 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:500

WB Dilution

1:200

Specificity

No cross-reactivity against GABABR2

ICC Dilution

1:100

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2108180

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