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Anti-Botch Antibody FL490 Conjugate

Our Anti-Botch mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N116/14. It detects human, mouse, and rat Botch, and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

Cation transport regulator-like protein 1, Glutathione-Specific Gamma-Glutamylcyclotransferase 1 or Botch1 is encoded by the gene CHAC1. Chac1 is a member of the gamma-glutamylcyclotransferase family. It is an enzyme that acts to catalyze the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Chac1 is involved in neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. CHAC1 is expressed in tissues including brain (forebrain and anterior spinal cord), and heart. Diseases associated with CHAC1 include Ovarian Embryonal Carcinoma and Ovarian Cancer.

Short Description

Our Anti-Botch mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N116/14. It detects human, mouse, and rat Botch, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1) (Neuroprotective protein 7)

Gene Name

Chac1 Botch Npg7

UniProt

B3STU3

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-222 (full-length) of rat Botch1 (accession number B3STU3.1) produced recombinantly in E. Coli

Target

Botch

Clonality

Monoclonal

Isotype

IgG1

Clone

N116/14

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Neurogenesis and Development

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

25 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity against Botch2/Chac2

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939668

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