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Anti-Pan-GRK FL594 Conjugate

Our Anti-Pan-GRK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N145/20. It detects human, mouse, and rat Pan-GRK, and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

G protein-coupled receptor (GPCR) kinases (GRKs), are important regulators of GPCR function and mediate receptor desensitization, internalization, and signaling. Several non-GPCR proteins also serve as GRK substrates, and GRKs have been shown to have kinase-independent functions through regulation of receptors and effectors. These proteins are members of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. GRKs phosphorylate activated forms of G protein-coupled receptors to regulate their signaling.

Short Description

Our Anti-Pan-GRK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N145/20. It detects human, mouse, and rat Pan-GRK, and is purified by protein a chromatography. It is great for use in ICC.

Synonyms

G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

Gene Name

Grk5 Gprk5 Grk6 Gprk6

UniProt

Q8VEB1

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (accession number Q8VEB1) produced recombinantly in E. Coli

Target

Pan-GRK

Clonality

Monoclonal

Isotype

IgG1

Clone

N145/20

Type

Primary Antibody

Applications

ICC

Field of Research

Cell Signaling/G Protein Signaling

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

70 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Cross-reacts with GRK6

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

WB Brain Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2939662

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