MRT67307

MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells[2].

Product Specifications

CAS Number

[1190378-57-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; IKK; ULK

Type

Reference compound

Related Pathways

Autophagy; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/MRT67307.html

Concentration

10mM

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCCNC1=NC(NC2=CC=CC(CN3CCOCC3)=C2)=NC=C1C4CC4)C5CCC5

Molecular Formula

C26H36N6O2

Molecular Weight

464.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434 (1) :93-104.|[2]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR) -dependent autophagy. J Biol Chem. 2015 May 1;290 (18) :11376-83.|[3]Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4 (4) :452-65.