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Anti-GABA-A-R, Delta Antibody FL490 Conjugate

Our Anti-GABA (A) R, Delta mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N151/3. It detects mouse and rat GABA (A) R, Delta, and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

Gamma-aminobutyric acid receptor subunit delta or Delta GABA-A receptor is encoded by the gene GABRD. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR delta is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR delta is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures.

Short Description

Our Anti-GABA (A) R, Delta mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N151/3. It detects mouse and rat GABA (A) R, Delta, and is purified by protein a chromatography. It is great for use in ICC.

Synonyms

Gamma-aminobutyric acid receptor subunit delta (GABA (A) receptor subunit delta)

Gene Name

Gabrd

UniProt

P18506

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Synthetic peptide amino acids 15-34 (CTQPHHGARAMNDIGDYVGS, extracellular N-terminus) of rat GABA-A-R-Delta (accession number P18506)

Target

GABA (A) R, Delta

Clonality

Monoclonal

Isotype

IgG2a

Clone

N151/3

Type

Primary Antibody

Applications

ICC

Field of Research

Neurotransmitter Receptors

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

55 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939628

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