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Anti-Nav1.8 Na+ Channel Antibody FL594 Conjugate

Our Anti-Nav1.8 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N134/12. It is KO validated, detects human, mouse, and rat Nav1.8 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

NAV1.8 is a member of the voltage-gated sodium channel family, which function in producing and propagating action potentials. Sodium channels are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Nav 1.8 is an integral membrane glycoprotein that is responsible for the initial rising phase of action in most excitable cells. Nav 1.8 is expressed in neurons in the dorsal root ganglion (DRG) . and appears to have a role in pain pathways.

Short Description

Our Anti-Nav1.8 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N134/12. It is KO validated, detects human, mouse, and rat Nav1.8 Na+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

Gene Name

Scn10a Sns

UniProt

Q62968

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (accession number Q62968) produced recombinantly in E. Coli

Target

Nav1.8 Na+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

N134/12

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

220 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not react with Nav1.7

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2939614

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