IL-2R beta/CD122, Canine (HEK293, His)

IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately)[1]. IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2]. IL-2R beta/CD122 Protein, Canine (HEK293, His) is a recombinant canine IL-2R betawith a C-Terminal His tag, which is produced in HEK293 cells.

NADTSKLTCF YNSKANISCI WSWDGDLQAT SCKIHAQPDR RPWNKSCELL PMRPAFWACY LILGSPDAQS LTSADVVGMS VMCHEGERWR ILMTQDFKPF ENLRLMAPNG LQVADVGTHK CNITWKVPQS SHYIKRYLEF EARKRSPGHS WEEASLMALR QNQQWISLET LTPDTLYEFQ VRVRAQRGSH KTWSPWSQPL AFRTRPAARG KQSLPFP

[5]M Allouche, et al. Interleukin 2 receptors. Leuk Res. 1990;14(8):699-707.|[1]Xiujuan Zhou, et al. Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder ( Paralichthys olivaceus). Front Immunol. 2020 Sep 9;11:531792.|[2]R N Bamfordm, et al. The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A.1998 May|[3]Xiujuan Zhou, et al. Immunological characteristics of Interleukin-2 receptor subunit beta (IL-2Rβ) in flounder (Paralichtlys olivaceus): Implication for IL-2R function. Fish Shellfish Immunol. 2019 Oct;93:641-655.|[4]Akira Sakai, et al. The role of tumor-associated macrophages on serum soluble IL-2R levels in B-cell lymphomas. J Clin Exp Hematop. 2014;54(1):49-61.