(±) -Silybin

(±) -Silybin is the racemate of Silybin. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

Product Specifications

CAS Number

36804-17-8

Product Name Alternative

Silibinin (mixture of Silybin A and Silybin B)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/racemic-silybin.html

Purity

99.40

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](C2=CC(OC)=C(C=C2)O)OC3=CC([C@H]4OC5=CC(O)=CC(O)=C5C([C@@H]4O)=O)=CC=C3O1

Molecular Formula

C25H22O10

Molecular Weight

482.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20 (9) :2190.|[2]Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.