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Anti-Copper ATPase 1 (Menke's Disease Protein) Antibody

Our Anti-Copper ATPase 1 (Menke's disease protein) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L60/4. It is KO validated, detects human, mouse, and rat Copper ATPase 1 (Menke's disease protein), and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

Copper-transporting ATPase 1 or ATPase Copper Transporting Alpha is encoded by the gene ATP7A and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 1 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the Golgi network and is also to remove excess copper across plasma membranes out of the cell. Copper-transporting ATPase 1 is found in most tissues except liver. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome.

Short Description

Our Anti-Copper ATPase 1 (Menke's disease protein) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L60/4. It is KO validated, detects human, mouse, and rat Copper ATPase 1 (Menke's disease protein), and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein)

Gene Name

ATP7A MC1 MNK

UniProt

Q04656

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 42-61 (cytoplasmic N- terminus) of human Copper-transporting ATPase 1 (accession number Q04656)

Target

Copper ATPase 1 (Menke's disease protein)

Clonality

Monoclonal

Isotype

IgG2b

Clone

L60/4

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Transporter Proteins

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.68

Molecular Weight

180 kDa in rat brain membrane preparations

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_2062824

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