Anti-Kv3.4 K+ Channel Antibody FL490 Conjugate

Potassium voltage-gated channel subfamily C member 4 or Kv3.4 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4) . Kv3.4 is primarily expressed in brain and found in the cerebellum, hippocampus, brain stem and spinal cord. It has also been found in skeletal and arterial smooth muscle. Kv3.4 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc4) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy. Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease and has been implicated in chronic hypoxia and Parkinson’s disease.

Our Anti-Kv3.4 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N72/16. It detects human, mouse, and rat Kv3.4 K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.