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Anti-Pan-Kvbeta K+ Channel Antibody FL650 Conjugate

Our Anti-Pan-Kvbeta K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K40/17. It detects human, mouse, and rat Pan-Kvbeta K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvβs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.

Short Description

Our Anti-Pan-Kvbeta K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K40/17. It detects human, mouse, and rat Pan-Kvbeta K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K (+) channel subunit beta-1) (Kv-beta-1) Voltage-gated potassium channel subunit beta-3 (K (+) channel subunit beta-3) (Kv-beta-3) (RCK beta3) Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K (+) channel subunit beta-2) (Kv-beta-2)

Gene Name

Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3

UniProt

P63144

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-401 (full-length) of rat Kv1 (accession number P63144) produced recombinantly in E. Coli

Target

Pan-Kvbeta K+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

K40/17

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

30-45 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939399

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