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Anti-BKbeta3a K+ Channel Antibody FL490 Conjugate

Our Anti-BKbeta3a K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N40B/18. It detects human, mouse, and rat BKbeta3a K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Calcium-activated potassium channel subunit beta-3, Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3 or BKBeta3a is encoded by the gene KCNMB3. BKbeta3a can bind to KCNMA1 to form a channel in the calcium activated large conductance (MaxiK channel) family. BKbeta3a acts to modulate the calcium sensitivity and gating kinetics of KCNMA1. It is widely expressed in tissues, and is present in several isoforms. Diseases associated with this gene include Familial Febrile Seizures.

Short Description

Our Anti-BKbeta3a K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N40B/18. It detects human, mouse, and rat BKbeta3a K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Potassium large conductance calcium-activated channel, subfamily M, beta member 3

Gene Name

Kcnmb3

UniProt

Q08460

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a (accession number Q08460) produced recombinantly in E. Coli

Target

BKbeta3a K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

N40B/18

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

32 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

ICC Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939364

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