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Anti-Kir2.3 K+ Channel Antibody

Our Anti-Kir2.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N25/35. It detects human, mouse, and rat Kir2.3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Inward rectifier potassium channel 4 or Kir2.3 is encoded by the gene KCNJ4. Kir2.3 is a member of the inward rectifier potassium ion channel family and plays a role in excitability of muscle cells and neurons. Kir2.3 is an integral membrane protein that is found expressed in heart, skeletal muscle, and several different brain regions including the hippocampus. Diseases associated with KCNJ4 include Long Qt Syndrome 9 and Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance.

Short Description

Our Anti-Kir2.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N25/35. It detects human, mouse, and rat Kir2.3 K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K (+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)

Gene Name

KCNJ4 IRK3

UniProt

P48050

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 390-445 of human Kir2.3 (accession number NP_032453) produced recombinantly in E. Coli

Target

Kir2.3 K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

N25/35

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

45 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

WB Dilution

1:1000

Specificity

No cross-reactivity against Kir2.1 or Kir2.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2130742

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