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Anti-Cavbeta2 Ca2+ Channel Antibody FL490 Conjugate

Our Anti-Cavbeta2 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N8B/1. It detects human, mouse, and rat Cavbeta2 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in CM, IHC, ICC.

Product Specifications

Background

Voltage-dependent L-type calcium channel subunit beta-2 or Cav ß2 is encoded by the gene CACNB2. Cavß2 is a cytoplasmic subunit of L type voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß2 is expressed heart and brain, and lung. Mutations in this gene are associated with Brugada syndrome.

Short Description

Our Anti-Cavbeta2 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N8B/1. It detects human, mouse, and rat Cavbeta2 Ca2+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2)

Gene Name

Cacnb2 Cacnlb2

UniProt

A0A0G2JSZ0

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 189-205 of rat Cav2 (RSPKPSANSVTSPHSKE; accession number A0A0G2JSZ0)

Target

Cavbeta2 Ca2+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

N8B/1

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Ca2+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

78 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Cavβ1, Cavβ3, Cavβ4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939272

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