What is the catalog number for Anti-Chapsyn-110/PSD-93 Antibody?

The catalog number for Anti-Chapsyn-110/PSD-93 Antibody is 75-057.

What sizes are available for Anti-Chapsyn-110/PSD-93 Antibody?

Anti-Chapsyn-110/PSD-93 Antibody is available in the following size(s): 100 µL.

Is Anti-Chapsyn-110/PSD-93 Antibody in stock?

Anti-Chapsyn-110/PSD-93 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Chapsyn-110/PSD-93 Antibody

Our Anti-Chapsyn-110/PSD-93 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N18/30. It is KO validated, detects human, mouse, rabbit, and rat Chapsyn-110/PSD-93, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Short Description

Our Anti-Chapsyn-110/PSD-93 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N18/30. It is KO validated, detects human, mouse, rabbit, and rat Chapsyn-110/PSD-93, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

Gene Name

Dlg2 Dlgh2

UniProt

Q63622

Host

Mouse

Reactivity

Human, Mouse, Rabbit, and Rat

Immunogen

Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli

Target

Chapsyn-110/PSD-93

Clonality

Monoclonal

Isotype

IgG1

Clone

N18/30

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Scaffold Proteins

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

110 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:500

WB Dilution

1:1000

Specificity

No cross-reactivity against other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells

ICC Dilution

1:100

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.