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Anti-Cavbeta1 Ca2+ Channel Antibody FL650 Conjugate

Our Anti-Cavbeta1 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N7/18. It detects human, mouse, non-human primate, and rat Cavbeta1 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Voltage-dependent L-type calcium channel subunit beta-1 or Cav ß1 is encoded by the gene CACNB1. Cavß1 is a cytoplasmic subunit of L type voltage-sensitive calcium channels. These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cavß1 serves to regulate the activity of L-type calcium channels. Cavß1 expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Diseases associated with CACNB1 include Malignant Hyperthermia and epileptic encephalopathy.

Short Description

Our Anti-Cavbeta1 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N7/18. It detects human, mouse, non-human primate, and rat Cavbeta1 Ca2+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)

Gene Name

CACNB1 CACNLB1

UniProt

Q02641

Host

Mouse

Reactivity

Human, Mouse, Non-Human Primate, and Rat

Immunogen

Synthetic peptide amino acids 19-34 of rat Cav1 (PMEVFDPSPQGKYSKR; accession number NP_059042)

Target

Cavbeta1 Ca2+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

N7/18

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Ca2+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

80, 55 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Cavβ2, Cavβ3, Cavβ4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939231

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