Desloratadine (Standard)

Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

Product Specifications

CAS Number

[100643-71-8]

Product Name Alternative

Sch34117 (Standard)

UNSPSC

12352005

Hazard Statement

H302-H318-H361-H411

Target

Drug Metabolite; Endogenous Metabolite; Histamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/desloratadine-standard.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1

Molecular Formula

C19H19ClN2

Molecular Weight

310.82

Precautions

P264-P270-P273-P280-P305+P351+P338-P330-P391-P405-P501

References & Citations

[1]McClellan K, et al. Desloratadine. Drugs. 2001;61 (6) :789-797.|[2]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107 (4) : p. 751-62.|[3]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31 (9) : p. 1369-77.|[4]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H (1) receptor. Eur J Pharmacol, 2002. 449 (3) : p. 229-37.