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Anti-Pan-MAGUK Antibody

Our Anti-Pan-MAGUK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K28/86. It detects human, mouse, rat, Xenopus, and zebrafish Pan-MAGUK, and is purified by Protein A chromatography. It is great for use in ICC, IP, WB.

Product Specifications

Background

Membrane-associated guanylate kinases (MAGUKs) are a large family of scaffold proteins that play essential roles in tissue development, cell-cell communication, cell polarity control, and cellular signal transduction. MAGUKs act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules and play key roles in cell-cell intercommunication. The neuronal synapse is a prime example of this, where the MAGUK proteins play a critical role in organizing both pre and post-synaptic proteins into functional assemblies. Major synaptic MAGUK proteins include PSD-95, SAP102, SAP97, PSD-93, CASK, and MAGIs. Together, they play roles in both synaptic development and in synaptic plasticity.

Short Description

Our Anti-Pan-MAGUK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K28/86. It detects human, mouse, rat, xenopus, and zebrafish Pan-MAGUK, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Gene Name

DLG1 DLG2 DLG3 KIAA1232 DLG4 PSD95

UniProt

P78352

Host

Mouse

Reactivity

Human, Mouse, Rat, Xenopus, and Zebrafish

Immunogen

Fusion protein amino acids 77-299 of human PSD-95/SAP90 produced recombinantly in E. Coli

Target

Pan-MAGUK

Clonality

Monoclonal

Isotype

IgG1

Clone

K28/86

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Scaffold Proteins

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

WB Dilution

1:1000

Specificity

Exhibits cross-reactivity against recombinant Chapsyn-110, SAP97 and SAP102

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Trial Size

1

Conjugate

Unconjugated

RRID

AB_10673115

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