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Anti-Pan-Neurofascin Antibody FL594 Conjugate

Our Anti-Pan-Neurofascin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L11A/41. It detects human and rat Pan-Neurofascin, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Short Description

Our Anti-Pan-Neurofascin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L11A/41. It detects human and rat Pan-Neurofascin, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Neurofascin NF-155 NF-186

Gene Name

Nfasc

UniProt

AAL27854

Host

Mouse

Reactivity

Human and Rat

Immunogen

Fusion protein 1066-1174 (intracellular domain common to NF-155 and NF-186) of rat NF-155 (accession number AAL27854) produced recombinantly in E. Coli

Target

Pan-Neurofascin

Clonality

Monoclonal

Isotype

IgG1

Clone

L11A/41

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Cell Adhesion Molecules/ Cell Markers/Neuronal Markers/Axonal Markers

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

155, 186 kDa (plus additional bands on immunoblot)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2939166

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