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Anti-Nav1.6 Na+ Channel Antibody FL490 Conjugate

Our Anti-Nav1.6 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K87A/10. It is KO validated, detects human, mouse, and rat Nav1.6 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016) .

Short Description

Our Anti-Nav1.6 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K87A/10. It is KO validated, detects human, mouse, and rat Nav1.6 Na+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)

Gene Name

Scn8a

UniProt

O88420

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420)

Target

Nav1.6 Na+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

K87A/10

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

<200 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939160

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