What is the catalog number for Anti-Nav1.2 Na+ Channel Antibody?

The catalog number for Anti-Nav1.2 Na+ Channel Antibody is 75-024.

What sizes are available for Anti-Nav1.2 Na+ Channel Antibody?

Anti-Nav1.2 Na+ Channel Antibody is available in the following size(s): 100 µL.

Is Anti-Nav1.2 Na+ Channel Antibody in stock?

Anti-Nav1.2 Na+ Channel Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Nav1.2 Na+ Channel Antibody

Our Anti-Nav1.2 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K69/3. It detects feline, human, mouse, non-human primate, and rat Nav1.2 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several cases of seizures, autism and bipolar disorders.

Short Description

Our Anti-Nav1.2 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K69/3. It detects feline, human, mouse, non-human primate, and rat Nav1.2 Na+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Sodium channel protein type 2 subunit alpha (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)

Gene Name

Scn2a Scn2a1

UniProt

P04775

Host

Mouse

Reactivity

Feline, Human, Mouse, Non-Human Primate, and Rat

Immunogen

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat rat Nav1.2 (accession number P04775) produced recombinantly in E. Coli

Target

Nav1.2 Na+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

K69/3

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

̃250 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:250

WB Dilution

1:500

IP Dilution

2.5 μg

Specificity

Lack of cross-reactivity against Nav1.1, Nav1.3, Nav1.6 verified

ICC Dilution

1:100

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.