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Anti-Slo1 Maxi-K+ Channel Antibody

Our Anti-Slo1 maxi-K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/60. It is KO validated, detects human, mouse, rat, and zebrafish Slo1 maxi-K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

MSlo maxi K+ channel (Calcium-activated potassium channel subunit alpha-1) is a member of BK channel alpha subunit family and has the particularity to be regulated by both Ca2+ and membrane depolarization.BK channels have a tetrameric structure. Each subunit is the product of the KCNMA1 gene. All modulatory subunits encoded by KCNMB1, KCNMB2, KCNMB3, or KCNMB4 can associate with the tetrameric channel. MSlo plays a major role in controlling cell excitability, which regulates smooth muscle contractions, transmitter release, and innate immune system cell activation. MSlo maxi-K+ channel contributes to repolarization of the membrane potential as it exports K+ out of the cytosol.

Short Description

Our Anti-Slo1 maxi-K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/60. It is KO validated, detects human, mouse, rat, sheep, and zebrafish Slo1 maxi-K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K (VCA) alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo)

Gene Name

Kcnma1 Kcnma

UniProt

Q08460-2

Host

Mouse

Reactivity

Human, Mouse, Rat, Sheep, and Zebrafish

Immunogen

Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (accession number AAA39746) produced recombinantly in E. Coli

Target

Slo1 maxi-K+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

L6/60

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

110-130 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:100

WB Dilution

1:500

Specificity

No cross-reactivity reported

ICC Dilution

1:100

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

WB Brain Quality Control

1

Trial Size

1

Conjugate

Unconjugated

RRID

AB_2249538

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