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Anti-Kvbeta2 K+ Channel Antibody FL650 Conjugate

Our Anti-Kvbeta2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K17/70. It is KO validated, detects finch, human, mouse, non-human primate, rat, and Xenopus Kvbeta2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Voltage-gated potassium channel subunit beta-2 or Kvß2 is encoded by the gene KCNAB2. Kvß2 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kvβ2 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. Kvβ2 is expressed in brain, in thecerebellum and in the juxtaparanodal region of nodes of Ranvier. Kvβ2 expression is also detected in lung, heart and kidney. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome and Juvenile Amyotrophic Lateral Sclerosis 16

Short Description

Our Anti-Kvbeta2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K17/70. It is KO validated, detects finch, human, mouse, non-human primate, rat, and xenopus Kvbeta2 K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K (+) channel subunit beta-2) (Kv-beta-2) (Neuroimmune protein F5)

Gene Name

Kcnab2 Ckbeta2 I2rf5 Kcnb3

UniProt

P62482

Host

Mouse

Reactivity

Finch, Human, Mouse, Non-Human Primate, Rat, and Xenopus

Immunogen

Fusion protein amino acids 1-367 (full length) of rat Kv2 (accession number NP_034728) produced recombinantly in E. Coli

Target

Kvbeta2 K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

K17/70

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

38 kDa (major band), 41 kDa (minor band)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939147

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