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Anti-Kvbeta1.1 K+ Channel Antibody FL650 Conjugate

Our Anti-Kvbeta1.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K9/40. It is KO validated, detects human, mouse, non-human primate, and rat Kvbeta1.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Voltage-gated potassium channel subunit beta-1 or Kvβ1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvβ1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3

Short Description

Our Anti-Kvbeta1.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K9/40. It is KO validated, detects human, mouse, non-human primate, and rat Kvbeta1.1 K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K (+) channel subunit beta-1) (Kv-beta-1)

Gene Name

Kcnab1 Kvb1

UniProt

P63143

Host

Mouse

Reactivity

Human, Mouse, Non-Human Primate, and Rat

Immunogen

Synthetic peptide amino acids 7-28 (unique N-terminus) of rat Kv1.1 (TEHNLKSRNGEDRLLSKQSST; accession number NP_058999)

Target

Kvbeta1.1 K+ channel

Clonality

Monoclonal

Isotype

IgG2b

Clone

K9/40

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

44 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Kvβ1.2, Kvβ1.3, Kvβ2

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

IHC Quality Control

1

RRID

AB_2939135

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