Anti-Kv4.2 K+ Channel Antibody FL650 Conjugate

Kv4.2 K+ channel (Potassium voltage-gated channel subfamily D member 2) is a member of the mammalian Shal-related family and potassium voltage gated channel subunit family. Kv4 subunit family includes four Kv4 α subunits (Kv4.1, Kv4.2 and Kv4.3) . However only Kv4.2 and Kv4.3 are predominantely expressed in the brain (Alfaro-Ruiz et al., 2019) . Kv4.2 K+ is encoded by gene KCND2 in human. It helps to regulate the action potential's circadian rhythm firing in suprachiasmatic nucleus neurons. This process regulates the circadian rhythm of locomotor activity. It has been demonstrated that Kv 4.2 and Kv4.3 are often colocalized with pain-modulating molecules in rat spinal lamina II excitatory interneurons (Huang et al., 2005) .

Our Anti-Kv4.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K57/1. It is KO validated, detects human, mouse, and rat Kv4.2 K+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.