What is the catalog number for Anti-Kv4.2 K+ Channel Antibody?

The catalog number for Anti-Kv4.2 K+ Channel Antibody is 75-016.

What sizes are available for Anti-Kv4.2 K+ Channel Antibody?

Anti-Kv4.2 K+ Channel Antibody is available in the following size(s): 100 µL.

Is Anti-Kv4.2 K+ Channel Antibody in stock?

Anti-Kv4.2 K+ Channel Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Kv4.2 K+ Channel Antibody

Our Anti-Kv4.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K57/1. It is KO validated, detects human, mouse, and rat Kv4.2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB, EM.

Product Specifications

Background

Kv4.2 K+ channel (Potassium voltage-gated channel subfamily D member 2) is a member of the mammalian Shal-related family and potassium voltage gated channel subunit family. Kv4 subunit family includes four Kv4 α subunits (Kv4.1, Kv4.2 and Kv4.3) . However only Kv4.2 and Kv4.3 are predominantely expressed in the brain (Alfaro-Ruiz et al., 2019) . Kv4.2 K+ is encoded by gene KCND2 in human. It helps to regulate the action potential's circadian rhythm firing in suprachiasmatic nucleus neurons. This process regulates the circadian rhythm of locomotor activity. It has been demonstrated that Kv 4.2 and Kv4.3 are often colocalized with pain-modulating molecules in rat spinal lamina II excitatory interneurons (Huang et al., 2005) .

Short Description

Our Anti-Kv4.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K57/1. It is KO validated, detects human, mouse, and rat Kv4.2 K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA, EM.

Synonyms

Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)

Gene Name

KCND2 KIAA1044

UniProt

Q9NZV8

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 209 –225 (extracellular S1-S2 loop) of rat Kv4.2 (CGSSPGHIKELPSGERY; accession number Q63881)

Target

Kv4.2 K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

K57/1

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA, EM

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

75-80 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:250

WB Dilution

1:1000

IP Dilution

2 μg

Specificity

No cross reactivity against rat Kv4.3

ICC Dilution

1:250

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.