What is the catalog number for Anti-Kv2.2 K+ Channel Antibody?

The catalog number for Anti-Kv2.2 K+ Channel Antibody is 75-015.

What sizes are available for Anti-Kv2.2 K+ Channel Antibody?

Anti-Kv2.2 K+ Channel Antibody is available in the following size(s): 100 µL.

Is Anti-Kv2.2 K+ Channel Antibody in stock?

Anti-Kv2.2 K+ Channel Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Kv2.2 K+ Channel Antibody

Our Anti-Kv2.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K37/89. It is KO validated, detects human, mouse, rabbit, and rat Kv2.2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999) . Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003) . Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996) .

Short Description

Our Anti-Kv2.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K37/89. It is KO validated, detects human, mouse, rabbit, and rat Kv2.2 K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)

Gene Name

KCNB2

UniProt

Q92953

Host

Mouse

Reactivity

Human, Mouse, Rabbit, and Rat

Immunogen

Fusion protein amino acids 1-61 of rat Kv2.2 (accession number Q63099) produced recombinantly in E. Coli

Target

Kv2.2 K+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

K37/89

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

125 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:500

WB Dilution

1:1000

IP Dilution

1 μg

Specificity

No cross-reactivity reported

ICC Dilution

1:500

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

Conjugate

Unconjugated

RRID

AB_2131665

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