What is the catalog number for Anti-Kv2.1 K+ Channel Antibody?

The catalog number for Anti-Kv2.1 K+ Channel Antibody is 75-014-020.

What sizes are available for Anti-Kv2.1 K+ Channel Antibody?

Anti-Kv2.1 K+ Channel Antibody is available in the following size(s): 20 µL.

Is Anti-Kv2.1 K+ Channel Antibody in stock?

Anti-Kv2.1 K+ Channel Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Kv2.1 K+ Channel Antibody

Our Anti-Kv2.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K89/34. It is KO validated, detects human, mouse, and rat Kv2.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Short Description

Our Anti-Kv2.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K89/34. It is KO validated, detects human, mouse, and rat Kv2.1 K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

Gene Name

Kcnb1

UniProt

P15387

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic C-terminus) of rat Kv2.1 (accession number P15387)

Target

Kv2.1 K+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

K89/34

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:500

WB Dilution

1:1000

Specificity

No cross-reactivity against rat Kv2.2

ICC Dilution

1:250

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.