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Anti-Pan-KChIP K+ Channel Antibody

Our Anti-Pan-KChIP K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K55/82. It detects human, mouse, and rat Pan-KChIP K+ channel, and is purified by Protein A chromatography. It is great for use in CHiP, IHC, ICC, IP, WB.

Product Specifications

Background

The Kv channel-interacting proteins (KChIP1, kChIp2, kChIp3, and kChIp4) are members of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin or neuronal calcium sensor (NCS) family branch of the EF-hand superfamily. They serve as auxiliary channel subunits and interact with Kv4 alpha subunits to form native Kv4 channel complexes. KChiP subunits regulate Kv4 channels through various mechanisms including altering: channel density, inactivation kinetics, rate of recovery from inactivation, and cell surface delivery.

Short Description

Our Anti-Pan-KChIP K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K55/82. It detects human, mouse, and rat Pan-KChIP K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA, ChIP.

Synonyms

Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1)

Gene Name

Kcnip1 Kchip1

UniProt

Q8R426

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-216 (full length) of rat KChIP1b (accession number Q8R426) produced recombinantly in E. Coli

Target

Pan-KChIP K+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

K55/82

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA, ChIP

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

33 kDa (KChIP2), 25 kDa (KChIP3/4), 22 kDa (KChIP1)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:250

WB Dilution

1:1000

IP Dilution

5 μg

Specificity

No cross-reactivity reported

ICC Dilution

1:250

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_10673406

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