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Anti-KChIP3 K+ Channel Antibody

Our Anti-KChIP3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K66/38. It is KO validated, detects human, mouse, and rat KChIP3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Product Specifications

Background

Kchip3 potassium channel, also known as Kv channel-interacting protein 3, Kcnip3, DREantagonist modulator and Dream is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin or neuronal calcium sensor (NCS) family branch of the EF-hand superfamily. Kchip3 is an integral subunit component of native Kv4 channel complexes that may regulate A-type currents and function as a calcium regulated transcriptional repressor. Kchip3 is detected in brain, specifically in the cortex, thalamus, dentate gyrus and cerebellum and can be found throughout the cell. It is also found in other tissues at low levels. Diseases associated with KCNIP3 include alzheimer disease.

Short Description

Our Anti-KChIP3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K66/38. It is KO validated, detects human, mouse, and rat KChIP3 K+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.

Synonyms

Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)

Gene Name

Kcnip3 Csen Dream Kchip3

UniProt

Q9JM47

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-256 (full length) of rat Calsenillin/DREAM/KChIP3 (accession number Q9JM47) produced recombinantly in E. Coli

Target

KChIP3 K+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

K66/38

Type

Primary Antibody

Applications

WB, IHC, ICC, IP, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Molecular Weight

34 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:250

WB Dilution

1:1000

Specificity

No cross-reactivity against rat KChIPs 1,2, 4

ICC Dilution

1:250

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2130257

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