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PARG-IN-4

PARG-IN-4 (Formula (A) ) is an orally available PARG inhibitor (EC50=1.9 nM) with cell membrane permeability. PARG-IN-4 can effectively inhibit tumor growth in mouse models. PARG-IN-4 can be used in cancer research[1].

Product Specifications

CAS Number

[2988890-20-4]

UNSPSC

12352005

Target

Apoptosis; Poly (ADP-ribose) Glycohydrolase (PARG)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parg-in-4.html

Purity

98.86

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC1(CC1)NS(=O)(C2=CC(N3C[C@@H](N[C@H](C3)C)C)=C(C=NN4C5=NN=C(C(F)F)S5)C4=C2)=O

Molecular Formula

C20H25F2N7O2S2

Molecular Weight

497.59

References & Citations

[1]Paul A Barsanti, et al. Piperazine substituted indazole compounds as inhibitors of parg. Patent WO2023183850A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 4

Available Sizes

Curated Selection

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