NH2-PEG8-acid

NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[756526-04-2]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-peg8-acid.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCN

Molecular Formula

C19H39NO10

Molecular Weight

441.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Michael Nathaniel ALONSO, et al. Antibody adjuvant conjugates. WO2018009916A1.|[2]"An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. "