Meclofenoxate (hydrochloride)

Meclofenoxate (Centrophenoxine) hydrochloride is an ester synthesized from DMAE and pCPA, capable of crossing the blood-brain barrier, and can stimulate memory and enhance cognition[1][2][3].

Product Specifications

CAS Number

[3685-84-5]

Product Name Alternative

Centrophenoxine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR; nAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/meclofenoxate-hydrochloride.html

Concentration

10mM

Purity

98.33

Solubility

DMSO : ≥ 50 mg/mL|H2O : 33.33 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(OCC(OCCN(C)C)=O)C=C1.Cl

Molecular Formula

C12H17Cl2NO3

Molecular Weight

294.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13 (4) :17-24.|[2]Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6 (2) :123-31.|[3]Zhang H, et al. Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson‘s Disease through Integrative Multi-omics analysis[J]. BioRxiv, 2023: 2023.04. 07.536024.