Dovitinib (lactate)
Product Specifications
UNSPSC Description
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
Target Antigen
c-Kit; FGFR; FLT3; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dovitinib-lactate.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O
Molecular Weight
482.51
References & Citations
[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10207/Dovitinib-lactate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10207/Dovitinib-lactate-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
692737-80-7
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal DNA Polymerase epsilon subunit 3 Antibody [Alexa Fluor 405]](https://cdn.genprice.uk/genprice/genprice2.png)
NB100-60438AF405 0.1 mL
Rabbit Polyclonal DNA Polymerase epsilon subunit 3 Antibody [Alexa Fluor 405]
Ask
View Details 
MBS9362815 Inquire
Cavy Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H) ELISA Kit
Ask
View Details 
