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Dovitinib (lactate)

Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].

Product Specifications

CAS Number

[692737-80-7]

Product Name Alternative

CHIR-258 lactate; TKI-258 lactate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Kit; FGFR; FLT3; PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dovitinib-lactate.html

Purity

99.75

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O

Molecular Formula

C24H27FN6O4

Molecular Weight

482.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t (4;14) multiple myeloma. Blood. 2005, 105 (7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56 (3), 595-601.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

Citation 01

Nat Commun. 2025 Jul 24;16 (1) :6777.|Biochemistry for Health, NOVA University of Lisbon. 2019 Jul.|bioRxiv. 2024 June 09.|Front Cell Dev Biol. 2020 May 7:8:287.|Harvard Medical School LINCS LIBRARY|J Biol Chem. 2023 Apr;299 (4) :104595|NPJ Precis Oncol. 2021 Jul 16;5 (1) :66.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Theranostics. 2018 Jul 30;8 (15) :4262-4278.|University of Düsseldorf. 2024.

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