(1S,2S) -ML-SI3

(1S,2S) -ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S) -ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) [1].

Product Specifications

CAS Number

[2563870-87-9]

Product Name Alternative

(+) -trans-ML-SI3

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1s-2s-ml-si3.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2

Molecular Formula

C23H31N3O3S

Molecular Weight

429.58

References & Citations

[1]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.