(1S,2S) -ML-SI3
(1S,2S) -ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S) -ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) [1].
Product Specifications
CAS Number
2563870-87-9
Product Name Alternative
(+) -trans-ML-SI3
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1s-2s-ml-si3.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
References & Citations
[1]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPML1; TRPML2; TRPML3
Available Sizes
Frequently Asked Questions
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