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Anti-Vitronectin Antibody

Our mouse Vitronectin monoclonal antibody from Antibodies Incorporated is produced in-house from clone HV23. It detects canine, feline, goat, horse, and human Vitronectin and is Protein A or Protein G purified. Works in ELISA, WB.

Product Specifications

Background

Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin. (2)

Synonyms

VTN, V75, VN, VNT, vitronectin, complement S-protein, epibolin, serum spreading factor, somatomedin B

Gene Name

VTN

NCBI Gene ID

7448

UniProt

P04004

Host

Mouse

Reactivity

Canine, Feline, Goat, Horse, and Human

Immunogen

Human vitronectin purified from plasma by heparin-affinity chromatography

Target

Vitronectin

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

HV23

Type

Primary Antibodies

Applications

ELISA, WB

Concentration

1 mg/mL ±15%

Format

Protein A or Protein G purified

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Molecular Weight

65 kDa, 75 kDA

Shipping Conditions

Shipped on ice packs

Storage Conditions

2-8°C without exposure to light

Notes

BSA free

Specificity

CSI 003-23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin) . CSI 003-23 binds nearly as well to native vitronectin as to denatured. CSI 003-23 is a potent inhibitor of integrin-mediated cell adhesion to vitronectin and a moderate inhibitor of PAI-1 binding. Epitope is located in the somatomedin B domain

Brand

Antibodies Inc (via BioPorto acquisition)

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Frequently Asked Questions

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