Peanut procyanidin A

Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H2O2-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282) -induced ulcerative colitis[1][2].

Product Specifications

CAS Number

[1802175-67-2]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/peanut-procyanidin-a.html

Smiles

O[C@H]([C@H](C(C=C1)=CC(O)=C1O)O2)[C@H](C(C2=CC(O)=C3)=C3O)C4=C(O)C(O)=CC5=C4O[C@@](C6=CC=C(O)C(O)=C6)(O7)[C@H](O)[C@H]5C(C(O[C@@H]8C(C=C9)=CC(O)=C9O)=C%10C[C@@H]8O)=C7C=C%10O

Molecular Formula

C45H36O18

Molecular Weight

864.76

References & Citations

[1]Yan F, et al. Protective effect of procyanidin A-type dimers against H2O2-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway. Life Sci. 2021 Feb 1;266:118908. |[2]Huang B, et al. The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism. J Food Biochem. 2022 Jul;46 (7) :e14103.