Anti-SCNN1G/Gamma-Subunit Epithelial Sodium Channel Antibody

The epithelial sodium channel (ENaC) of the kidney is necessary for extracellular volume homeostasis and normal arterial BP. Activity of ENaC is enhanced by proteolytic cleavage of the y-subunit. In the y-subunit, putative cleavage sites for prostasin, kallikrein (similar site as prostasin), elastase, and plasmin exist. Prostasin is a glycosylphosphatidylinositol anchored apical serine protease expressed in the collecting duct that activates yENaC at a site close to but in the C-terminal direction to the furin cleavage with putative release of a 43-residue inhibitory tract. (1)

SCNN1G, BESC3, ENaCg, ENaCgamma, LDLS2, PHA1, PHA1B3, SCNEG, epithelial sodium channel subunit gamma, ENaC gamma subunit, ENaC subunit gamma, amiloride-sensitive epithelial sodium channel gamma subunit, amiloride-sensitive sodium channel gamma-subunit, amiloride-sensitive sodium channel subunit gamma, epithelial Na (+) channel subunit gamma, gamma-ENaC, gamma-NaCH, nonvoltage-gated sodium channel 1 subunit gamma, sodium channe epithelial 1 gamma subunit, sodium channel epithelial 1 gamma subunit, sodium channel, non-voltage-gated 1, gamma subunit, sodium channel, nonvoltage-gated 1, gamma

CAM 035-01 is specific for the neoepitope generated after proteolytic cleavage of human yENaC and recognizes the C-terminal fragment starting from amino acid residue 182.