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Anti-PYY (3-36) (peptide tyrosine-tyrosine amide, 3-36) Antibody

Our mouse PYY (3-36) (peptide tyrosine-tyrosine amide, 3-36) monoclonal antibody from Antibodies Incorporated is produced in-house from clone 4. It detects human PYY (3-36) (peptide tyrosine-tyrosine amide, 3-36) and is Protein A or Protein G purified. Works in ELISA, WB.

Product Specifications

Background

Peptide tyrosine-tyrosine amide (3-36), or PYY (3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY (3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY (3-36) is additive to that of the co-secreted gut hormone GLP-1.

Synonyms

PYY, PYY-I, PYY1, peptide YY, peptide tyrosine tyrosine, prepro-PYY

Gene Name

PYY

NCBI Gene ID

5697

UniProt

P10082

Host

Mouse

Reactivity

Human

Immunogen

Synthetic N-terminal fragment of human PYY (3-36) coupled to carrier.

Target

PYY (3-36) (peptide tyrosine-tyrosine amide, 3-36)

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

4

Type

Primary Antibodies

Applications

ELISA, WB

Concentration

1 mg/mL ±15%

Dilution

1:20,000

Format

Protein A or Protein G purified

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Molecular Weight

4 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

2-8°C without exposure to light

Notes

BSA free

Specificity

ABS 051-04 binds human PYY (3-36) . Based on inhibition ELISA, ABS 051-04 shows no cross-reaction with PYY (1-36) or NPY. The epitope lies within residues 3-12 of human PYY.

Brand

Antibodies Inc (via BioPorto acquisition)

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Frequently Asked Questions

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