Anti-Aprotinin Antibody

Aprotinin, also called bovine pancreatic trypsin inhibitor, is a single chain globular Kunitz-type serine proteinase inhibitor found in bovine pancreas, parotid gland and lung. It forms stable, enzymatically inactive complexes with trypsin, chymotrypsin, plasmin and kallikrein. Aprotinin has been used therapeutically as an antifibrinolytic agent under the name Trasylol (Bayer) to reduce blood loss during cardiopulmonary bypass surgery but this use has been associated with an increased frequency of acute renal injury.

ABS 037-35 binds bovine aprotinin immobilized on a solid phase or free in solution. The epitope of ABS 037-35 is different from the epitopes of ABS 037-18 and ABS 037-21.