L-Asparaginase

L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].

Product Specifications

CAS Number

[9015-68-3]

Product Name Alternative

L-ASNase

UNSPSC

12352204

Hazard Statement

H317, H361

Target

Apoptosis; DNA/RNA Synthesis

Type

Enzyme

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-asparaginase.html

Purity

99.91

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[L-Asparaginase]

Molecular Weight

34000 (monomer)

Precautions

H317, H361

References & Citations

[1] Ilaria M Michelozzi, et al. Acute myeloid leukaemia niche regulates response to L-asparaginase. Br J Haematol. 2019 Aug;186 (3) :420-430. doi: 10.1111/bjh.15920. |[2]T Ueno, et al. Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase. Leukemia. 1997 Nov;11 (11) :1858-61.