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CH-223191

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR) . CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1].

Product Specifications

CAS Number

301326-22-7

UNSPSC

12352005

Hazard Statement

H302

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CH-223191.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C

Molecular Formula

C19H19N5O

Molecular Weight

333.39

Precautions

H302

References & Citations

[1]Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl) -amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69 (6) :1871-8. Epub 2006 Mar 15.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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