CH-223191
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR) . CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1].
Product Specifications
CAS Number
301326-22-7
UNSPSC
12352005
Hazard Statement
H302
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CH-223191.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C
Molecular Formula
C19H19N5O
Molecular Weight
333.39
Precautions
H302
References & Citations
[1]Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl) -amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69 (6) :1871-8. Epub 2006 Mar 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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