Human IL-11 R alpha (Luc) HEK293 Reporter Cell
Human IL-11 R alpha (Luc) HEK293 Reporter Cell is expressed from Human HEK293.
Product Specifications
Background
IL-11 and IL-6 are signal transducer and activator of transcription 3 (STAT3) activators and frequently found upregulated in colorectal cancer (CRC) . STAT3 activation in tumor epithelial cells is critically involved in the pathogenesis of CRC. Cancer-associated fibroblasts (CAFs) can modulate the tumor microenvironment in CRC. The latest research indicated that phosphorylation of STAT3 (pSTAT3) expression in CAFs is inversely correlated with the survival in CRC patients. IL-6 and IL-11 induce partly overlapping gene expression patterns in fibroblast subsets in CRC. In a summary, STAT3 activation in CAFs plays a key role in the cross-talk to the tumor epithelium.
Host
HEK293
Origin Species
Human
Target
IL-11 R alpha
Tag
Luc
Applications
• Screen for anti-human IL-11 or anti-human IL-11 R alpha neutralizing antibody.
Format
Liquid
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
Frozen in liquid nitrogen
Package Size
1Vial*2
Host or Source
HEK293
Species
Human
Curated Selection
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